MLST8 blocking peptide product blog
Tags: Blocking Peptide; GBL; MLST8; MLST8 blocking peptide;
The MLST8 mlst8 (Catalog #MBS9224138) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MLST8 mlst8 product has the following accession number(s) (GI #74761285) (NCBI Accession #Q9BVC4.1) (Uniprot Accession #Q9BVC4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves an AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at \'Thr-389\', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient- poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum- induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \'Ser-473\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \'Thr-308\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \'Ser-422\'. mTORC2 also modulates the phosphorylation of PRKCA on \'Ser-657\'.
Cellular Location: Cytoplasm. Tissue Location: Broadly expressed, with highest levels in skeletal muscle, heart and kidney. MLST8 also interacts with the following gene(s): AKT1S1, DEPTOR, EIF4EBP1, MAPKAP1, MTOR, RHEB, RICTOR, RPTOR. Cardiomegaly, Fatty Liver, Heart Diseases, Hypertrophy, Kidney Diseases, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental, Prostatic Diseases are some of the diseases may be linked to GBL Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. Adipose Tissue, Blood, Brain, Connective Tissue, Heart, Kidney, Liver, Muscle, Prostate, Stomach tissues are correlated with this protein.