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MLN 2238 kinase inhibitor product blog

Posted on 2016-03-03 13:45:46 by mybiosource_staff
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Tags: Kinase Inhibitor; MLN 2238; MLN 2238 kinase inhibitor;
The MLN 2238 n/a (Catalog #MBS8506503) is a Kinase Inhibitor and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given kinase inhibitor. We\'ve tested the MLN 2238 with the following immunoassay(s):
Testing Data
Testing Data MLN 2238.

MLN2238 is a potent reversible and specific beta5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. Proteasome activity was inhibited greater than 50% for up to 8 hrs following the IV dose in both blood and tumor, whereas proteasome activity recovered more quickly following the SC dose. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment. [1][2].

Solubility: DMSO >=72 mg/mL - Water <1 mg/mL - Ethanol >=9 mg/mL. Formula: C14H19BCl2N2O4
CAS Number: 1072833-77-2.
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