MLF1 blocking peptide product blog
Tags: Blocking Peptide; MLF1; MLF1 blocking peptide;
The MLF1 mlf1 (Catalog #MBS9229923) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MLF1 mlf1 product has the following accession number(s) (GI #17368170) (NCBI Accession #P58340.1) (Uniprot Accession #P58340). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Cellular Location: Cytoplasm. Nucleus. Note: In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus. Found in the nucleolus when fused to NPM. Tissue Location: Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. Bone, Bone Marrow, Embryonic Tissue, Eye, Heart, Kidney, Muscle, Nerve, Ovary, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Chromosome Breakage, Congenital Abnormalities, Disease Models, Animal, Leukemia, Myeloid, Acute, Neoplasms, Experimental, Prostatic Neoplasms, Stomach Neoplasms are some of the diseases may be linked to MLF1 Blocking Peptide (C-term).