|The mGRO b cxcl2 (Catalog #MBS142045) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.
The mGRO b cxcl2 product has the following accession number(s) (GI #6677885) (NCBI Accession #NP_033166.1) (Uniprot Accession #P10889). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV IATLKGGQKV CLDPEAPLVQ KIIQKILNKG KAN.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including GRO-beta/MIP-2 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Solubility: It is recommended to reconstitute the lyophilized GRO-beta Mouse in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Protein Content: Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 0.015 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of GRO-b as a Reference Standard.
Biological Activity: The Biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 105-106units/mg. Bone Marrow, Mammary Gland, Pancreas, Skin, Spleen, Uncharacterized Tissue, Vagina tissues are correlated with this protein. The following patways have been known to be associated with this gene. Disease Models, Animal, Edema, Inflammation, Lung Diseases, Lung Injury, Necrosis, Pneumonia, Reperfusion Injury, Skin Diseases, Wounds and Injuries are some of the diseases may be linked to Recombinant Mouse GRO-beta/MIP-2 (CXCL2).