MFN2 blocking peptide product blog
Tags: Blocking Peptide; Mitofusin 2; MFN2; MFN2 blocking peptide;
The MFN2 mfn2 (Catalog #MBS543984) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Mitofusin 2 can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion.Immunoprecipitation: 1:200
Western Blot: 1:500. Researchers should empirically determine the suitability of the MFN2 mfn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MFN2 mfn2 product has the following accession number(s) (GI #7662004) (NCBI Accession #NP_055689) (Uniprot Accession #O95140). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Immunogen: Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.
Immunoglobulin: IgG
Expression: Ubiquitous; expressed at low level. Highly expressed in heart and kidney. Molecular Function: Hydrolase; GTP-binding, Nucleotide binding
Structure: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA famil. Mitofusin subfamily. Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. MFN2 also interacts with the following gene(s): BAK1, DNM1L, FIS1, MARCH5, PARK2, PINK1, RAB7A, UBC. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Congenital Abnormalities, Disease Models, Animal, Heart Diseases, Hyperplasia, Inflammation, Liver Diseases, Muscular Diseases, Nervous System Diseases, Peripheral Nervous System Diseases are some of the diseases may be linked to Mitofusin 2 Peptide. Blood, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Nerve, Vascular tissues are correlated with this protein.