Mertk blocking peptide product blog
Tags: Blocking Peptide; MERTK; MERTK blocking peptide;
The Mertk mertk (Catalog #MBS9230216) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Mertk mertk product has the following accession number(s) (GI #12643780) (NCBI Accession #Q60805.1) (Uniprot Accession #Q60805). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Cellular Location: Membrane; Single-pass type I membrane protein. Tissue Location: Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells and platelets. Bone Marrow, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Mammary Gland, Skin, Testis tissues are correlated with this protein. Carcinoma, Disease Models, Animal, Fibrosis, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Nerve Degeneration, Nervous System Diseases, Retinitis Pigmentosa are some of the diseases may be linked to Mouse Mertk Blocking Peptide (C-term). The following patways have been known to be associated with this gene. Mertk also interacts with the following gene(s): Gas6, Pik3r1, Pros1, Rpe65, Tulp1.