MEN1 blocking peptide product blog
Tags: Blocking Peptide; MEN1; MEN1 blocking peptide; MEN1 (S128);
The MEN1 men1 (Catalog #MBS9226868) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MEN1 men1 product has the following accession number(s) (GI #18860839) (NCBI Accession #NP_000235) (Uniprot Accession #O00255). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates \'Lys-4\' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Cellular Location: Nucleus. Note: Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation. Tissue Location: Ubiquitous. The following patways have been known to be associated with this gene. MEN1 also interacts with the following gene(s): ASH2L, CTNNB1, JUND, MLL2, MLL4, MYC, RBBP5, SMAD2, SMAD3. Adenocarcinoma, Gastrinoma, Hyperplasia, Insulinoma, Kidney Diseases, Liver Neoplasms, Multiple Endocrine Neoplasia Type 1, Nervous System Diseases, Neuroendocrine Tumors, Pancreatic Neoplasms are some of the diseases may be linked to MEN1 Antibody (S128) Blocking Peptide. Adrenal Gland, Blood, Kidney, Liver, Lung, Lymph, Lymph Node, Pancreas, Thyroid, Vascular tissues are correlated with this protein.