Melk blocking peptide product blog
Tags: Blocking Peptide; MELK; MELK blocking peptide;
The Melk melk (Catalog #MBS9229900) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Melk melk product has the following accession number(s) (GI #341940950) (NCBI Accession #Q61846.2) (Uniprot Accession #Q61846). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Cellular Location: Cell membrane; Peripheral membrane protein. Tissue Location: Expressed in testis, ovary, thymus, spleen and T-cell. Expressed by neural progenitors: highly enriched in cultures containing multipotent progenitors. Melk also interacts with the following gene(s): Bub1, Ccna2, Cdk1, Ncapg, Pbk, Rrm2. Acute Kidney Injury, Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Nervous System Diseases are some of the diseases may be linked to Melk Blocking Peptide (Center). Bone, Brain, Embryonic Tissue, Heart, Liver, Lung, Pancreas, Spleen, Testis, Thymus tissues are correlated with this protein.