|The MEF2C mef2c (Catalog #MBS9226024) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The MEF2C mef2c product has the following accession number(s) (GI #2500875) (NCBI Accession #Q06413.1) (Uniprot Accession #Q06413). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Cellular Location: Nucleus. Tissue Location: Expressed in brain and skeletal muscle. The following patways have been known to be associated with this gene. Disease Models, Animal, Epilepsy, Fetal Death, Fibrosis, Heart Diseases, Inflammation, Intellectual Disability, Liver Diseases, Lung Diseases, Necrosis are some of the diseases may be linked to MEF2C Antibody (T300) Blocking Peptide. Blood, Bone Marrow, Brain, Connective Tissue, Embryonic Tissue, Heart, Muscle, Nerve, Skin, Vascular tissues are correlated with this protein.