MeCP2 positive control product blog
Tags: MECP2; Positive Control; MeCP2 positive control; MeCP2 isoform 2;
The MeCP2 mecp2 (Catalog #MBS542950) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s MeCP2 isoform 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western Blot: 1:500. Researchers should empirically determine the suitability of the MeCP2 mecp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MeCP2 mecp2 product has the following accession number(s) (GI #1708973) (NCBI Accession #P51608.1) (Uniprot Accession #P51608). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Western Blot Positive Control Methyl-CpG-binding protein 2 isoform 2
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Immunogen: Purified Protein
Expression: Present in all adult somatic tissues tested. Molecular Function: Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding
Subcellular Location: Nucleus (Note: Colocalized with methyl-CpG in the genome). MeCP2 also interacts with the following gene(s): BDNF, DNMT1, DNMT3A, IRAK1, NCOR1, SIN3A, SPI1. Angelman Syndrome, Autistic Disorder, Child Development Disorders, Pervasive, Cognition Disorders, Developmental Disabilities, Intellectual Disability, Learning Disorders, Memory Disorders, Rett Syndrome, Seizures are some of the diseases may be linked to MeCP2 isoform 2 Positive Control. Bone, Brain, Embryonic Tissue, Eye, Heart, Liver, Lung, Muscle, Nerve, Prostate tissues are correlated with this protein.