|The MECP2 mecp2 (Catalog #MBS9225198) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The MECP2 mecp2 product has the following accession number(s) (GI #1708973) (NCBI Accession #P51608.1) (Uniprot Accession #P51608). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).
Cellular Location: Nucleus. Note: Colocalized with methyl-CpG in the genome. Tissue Location: Present in all adult somatic tissues tested. The following patways have been known to be associated with this gene. Angelman Syndrome, Autistic Disorder, Child Development Disorders, Pervasive, Cognition Disorders, Developmental Disabilities, Intellectual Disability, Learning Disorders, Memory Disorders, Rett Syndrome, Seizures are some of the diseases may be linked to Phospho-MeCP2(S80) Antibody Blocking peptide. Bone, Brain, Embryonic Tissue, Eye, Heart, Liver, Lung, Muscle, Nerve, Prostate tissues are correlated with this protein. MECP2 also interacts with the following gene(s): BDNF, DNMT1, DNMT3A, IRAK1, NCOR1, SIN3A, SPI1.