MBNL2 blocking peptide product blog
Tags: Blocking Peptide; MBNL2; MBNL2 blocking peptide;
The MBNL2 mbnl2 (Catalog #MBS9219592) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MBNL2 mbnl2 product has the following accession number(s) (GI #125952110) (NCBI Accession #Q5VZF2.2) (Uniprot Accession #Q5VZF2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5\'ACACCC-3\' core sequence, termed zipcode, within the 3\'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
Cellular Location: Nucleus. Cytoplasm. Note: Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts. Tissue Location: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Heart Diseases, Uterine Cervical Neoplasms are some of the diseases may be linked to MBNL2 Antibody (C-term) Blocking peptide. MBNL2 also interacts with the following gene(s): CEBPD, CELF1, CELF2, CNBP, DMPK, TNNT2. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Muscle, Nerve, Prostate, Skin tissues are correlated with this protein.