MARK1 (HGNC:6896) blocking peptide product blog
Tags: Blocking Peptide; MARK1; MARK1 (HGNC:6896) blocking peptide; MARK1 (HGNC:6896);
The MARK1 (HGNC:6896) mark1 (Catalog #MBS9226622) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MARK1 (HGNC:6896) mark1 product has the following accession number(s) (GI #124056494) (NCBI Accession #Q9P0L2.2) (Uniprot Accession #Q9P0L2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Cellular Location: Cell membrane; Peripheral membrane protein Cytoplasm, cytoskeleton. Note: Appears to localize to an intracellular network. Tissue Location: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. Brain, Embryonic Tissue, Eye, Heart, Intestine, Kidney, Lung, Nerve, Skin, Stomach tissues are correlated with this protein. MARK1 (HGNC:6896) also interacts with the following gene(s): MAP2, MAPT, MARK2, STK11. Cardiovascular Diseases, Cell Transformation, Neoplastic, Cognition Disorders, Disease Models, Animal, Inflammation, Liver Diseases, Lung Neoplasms, Necrosis, Nervous System Diseases, Stomach Neoplasms are some of the diseases may be linked to MARK1 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene.