MAPK14 blocking peptide product blog
Tags: Blocking Peptide; MAPK14; MAPK14 blocking peptide; Phospho-MAPK14;
The MAPK14 mapk14 (Catalog #MBS544293) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Phospho-MAPK14 can be used in a range of immunoassay formats including, but not limited to, Immunocompeition, Immunodepletion.Western Blot: 1:500-1:1,000. Researchers should empirically determine the suitability of the MAPK14 mapk14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MAPK14 mapk14 product has the following accession number(s) (GI #4503069) (NCBI Accession #NP_001306) (Uniprot Accession #Q16539). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Antigenic Blocking Peptide Phospho p38 Mitogen Activated Protein Kinase 14 Antibody
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation.
Immunogen: Synthetic Peptide
Expression: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney. Modification: Phosphorylated
Molecular Function: ATP binding; MAP kinase activity; MAP kinase kinase activity; NFAT protein binding; Protein serine/threonine kinase activity
Structure: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B.
Subcellular Location: Cytoplasm; Nucleus. Cell Transformation, Neoplastic, Fibrosis, Heart Diseases, Inflammation, Liver Diseases, Lung Neoplasms, Myocardial Ischemia, Necrosis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Phospho MAPK14 Antibody Antigenic Blocking Peptide. MAPK14 also interacts with the following gene(s): ATF2, CREB1, DUSP1, DUSP16, JUN, MAP2K3, MAP2K6, MAPKAPK3, MEF2A, TAB1. Blood, Bone, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein.