Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Blog  rightarrow MAPK12 blocking peptide  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • anti-RELA antibody blog
 • NEK3 sirna blog
 • anti-CAV1 antibody blog
 • TMEM173 blocking peptide blog
 • CAPN6 shrna blog
 • Kemptide substrate blog
 • SAP130 sirna blog
 • RBFOX1 sirna blog
 • Muc13 recombinant protein blog
 • KCNJ14 shrna blog
 • MAPT blocking peptide blog
 • anti-COL18A1 antibody blog
 • Fibronectin Adhesion-Promoting Peptide biologically active peptide blog
 • THRB blocking peptide blog
 • Diablo blocking peptide blog
 • Mouse F(ab')2 Anti-Human CD20 secondary antibody blog
 • anti-MELATONIN antibody blog
 • KSR2 sirna blog
 • CALHM3 sirna blog
 • rno-miR-191a-3p mirna blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • transmembrane protein 176B (Tmem176b) Antibody
 • Complement 3b (C3b) ELISA Kit
 • Albumin Native Protein
 • alpha1-AGP (Alpha-1-Acid Glycoprotein) CLIA Kit
 • D-Pantothenic acid (vitamin B5) (BSA) conjugate Antigen
 • IgG Antibody
 • nudE nuclear distribution gene E homolog 1 (A. nidulans) (N... Antibody
 • ATP1A1 Antibody
 • Ferroportin (FPN) ELISA Kit
 • Cannabinoid (THC) Antibody
 • FK-506 Antibody
 • GSTA4 Recombinant Protein
 • CD160 molecule ELISA Kit
 • calcium channel, voltage-dependent, alpha 2-delta subunit 1 ... ELISA Kit
 downarrow more ...

MAPK12 blocking peptide product blog

Posted on 2017-11-23 04:58:49 by mybiosource_staff
Share it on ...     
Tags: MAPK12; Blocking Peptide; MAPK12 blocking peptide;
The MAPK12 mapk12 (Catalog #MBS9226957) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The MAPK12 mapk12 product has the following accession number(s) (GI #2851522) (NCBI Accession #P53778.3) (Uniprot Accession #P53778). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma- radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

MAPK12 mapk12

Cellular Location: Cytoplasm. Nucleus. Mitochondrion. Note: Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). Tissue Location: Highly expressed in skeletal muscle and heart. Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Edema, Growth Disorders, Inflammation, Learning Disorders, Memory Disorders, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to MAPK12 Antibody (C-term) Blocking peptide. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Kidney, Liver, Lung, Mammary Gland, Muscle, Prostate, Uterus tissues are correlated with this protein.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions