Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Blog  rightarrow MAPK12 blocking peptide  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • ITGA5 blocking peptide blog
 • anti-PDE6C antibody blog
 • AFP blocking peptide blog
 • RHPN1 sirna blog
 • ETO1 recombinant protein blog
 • rno-miR-142-3p mirna blog
 • SAA1 recombinant protein blog
 • STRIP2 blocking peptide blog
 • ZSCAN21 sirna blog
 • P2RX5 sirna blog
 • MED14 sirna blog
 • Parainfluenza 3, Strain C243 native protein blog
 • anti-YWHAB antibody blog
 • anti-EIF2AK2 antibody blog
 • IL12B recombinant protein blog
 • KCNK16 shrna blog
 • anti-H-2Ld (public; H-2.m65) antibody blog
 • PCK2 enzyme blog
 • 5-HT elisa kit blog
 • IFI202 sirna blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • Schneider's Insect Medium w-L-Glutamine, w-o Sodium Bicarbon... Culture Media
 • FANCD2 Antibody
 • Period Circadian Protein 2 (PER2) ELISA Kit
 • ALX3 Antibody
 • BACE2 Antibody
 • Beta-secretase 2 (Bace2) ELISA Kit
 • Methyl CpG Binding Domain Protein 2 (MBD2) Recombinant Protein
 • Activin-B Recombinant Protein
 • Glypican-3 (GPC3) Antibody
 • TIMP3 ELISA Kit
 • FCGR3A siRNA
 • Arginase 1 (ARG1) Blocking Peptide
 • Human IgG1 lambda Isotype Control Isotype Control
 • IFN GAMMA (IFNG) Antibody
 downarrow more ...
separator

MAPK12 blocking peptide product blog

separator
Posted on 2017-11-23 04:58:49 by mybiosource_staff
Share it on ...     
separator
separator
Tags: MAPK12; Blocking Peptide; MAPK12 blocking peptide;
separator
The MAPK12 mapk12 (Catalog #MBS9226957) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.

The MAPK12 mapk12 product has the following accession number(s) (GI #2851522) (NCBI Accession #P53778.3) (Uniprot Accession #P53778). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma- radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

MAPK12 mapk12

Cellular Location: Cytoplasm. Nucleus. Mitochondrion. Note: Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). Tissue Location: Highly expressed in skeletal muscle and heart. Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Edema, Growth Disorders, Inflammation, Learning Disorders, Memory Disorders, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to MAPK12 Antibody (C-term) Blocking peptide. Blood, Bone, Brain, Kidney, Liver, Lung, Mammary Gland, Muscle, Prostate, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions