|The Map2k4 map2k4 (Catalog #MBS9221232) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Map2k4 map2k4 product has the following accession number(s) (GI #2507202) (NCBI Accession #P47809.2) (Uniprot Accession #P47809). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Cellular Location: Cytoplasm. Nucleus. Tissue Location: Strong expression is detected in most of the central nervous system and in liver and thymus during early stages of development. While expression in nervous system increases over time, expression in fetal liver and thymus gradually decreases as embryogenesis proceeds. High level of expression in the central nervous system persists throughout postnatal development and remained at a stable level in adult brain. Adenocarcinoma, Brain Diseases, Breast Neoplasms, Inflammation, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasms, Experimental, Pancreatic Neoplasms, Prostatic Neoplasms are some of the diseases may be linked to Mouse Map2k4 Antibody (C-term) Blocking Peptide. Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Lymph Node, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene.