MAP2K1 blocking peptide product blog
Tags: MAP2K1; Blocking Peptide; MEK1 (MAP2K1); MAP2K1 blocking peptide;
The MAP2K1 map2k1 (Catalog #MBS9227409) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MAP2K1 map2k1 product has the following accession number(s) (GI #400274) (NCBI Accession #Q02750.2) (Uniprot Accession #Q02750). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm Nucleus. Note: Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. Tissue Location: Widely expressed, with extremely low levels in brain. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Breast Neoplasms, Cardiovascular Diseases, Heart Diseases, Inflammation, Lung Neoplasms, Melanoma, Necrosis, Neoplasm Invasiveness, Neoplasm Metastasis, Nervous System Diseases are some of the diseases may be linked to MEK1 (MAP2K1) Antibody (N-term) Blocking peptide. The following patways have been known to be associated with this gene. MAP2K1 also interacts with the following gene(s): ARAF, BRAF, HRAS, KSR1, MAP3K1, MAPK1, MAPK14, MAPK3, RAF1, YWHAB.