MAP1LC3B blocking peptide product blog
Tags: Blocking Peptide; MAP1LC3B; MAP1LC3B blocking peptide; LC3 (APG8B);
The MAP1LC3B map1lc3b (Catalog #MBS9223056) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MAP1LC3B map1lc3b product has the following accession number(s) (GI #17433141) (NCBI Accession #Q9GZQ8.3) (Uniprot Accession #Q9GZQ8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Cellular Location: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes Localizes also to discrete punctae along the ciliary axoneme (By similarity). Tissue Location: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. Breast Neoplasms, Disease Models, Animal, Fibrosis, Inflammation, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental, Nervous System Diseases, Prostatic Neoplasms are some of the diseases may be linked to LC3 Antibody (APG8B) (C-term) Blocking peptide. Blood, Brain, Kidney, Liver, Lung, Lymph, Lymph Node, Muscle, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. MAP1LC3B also interacts with the following gene(s): ATG12, ATG3, ATG4A, ATG4B, ATG5, ATG7, BNIP3, SQSTM1, ULK1.