MAD2L2 blocking peptide product blog
Tags: Blocking Peptide; MAD2L2; MAD2L2 blocking peptide;
The MAD2L2 mad2l2 (Catalog #MBS9229289) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The MAD2L2 mad2l2 product has the following accession number(s) (GI #12643889) (NCBI Accession #Q9UI95.2) (Uniprot Accession #Q9UI95). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Cellular Location: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Tissue Location: Ubiquitously expressed. MAD2L2 also interacts with the following gene(s): ADAM9, CDC20, CDH1, FZR1, POLE, PRCC, REV1, REV3L. Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Lymph, Lymph Node, Prostate, Testis tissues are correlated with this protein. Adenocarcinoma, Brain Diseases, Carcinoma, Carcinoma, Hepatocellular, Congenital Abnormalities, Kidney Diseases, Nervous System Diseases, Ovarian Diseases, Prostatic Diseases, Prostatic Neoplasms are some of the diseases may be linked to MAD2L2 Blocking Peptide (C-term). The following patways have been known to be associated with this gene.