|The LRRK2 lrrk2 (Catalog #MBS9226585) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The LRRK2 lrrk2 product has the following accession number(s) (GI #171846278) (NCBI Accession #NP_940980) (Uniprot Accession #Q5S007). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
Cellular Location: Membrane; Peripheral membrane protein. Cytoplasm. Perikaryon. Mitochondrion. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endosome. Lysosome. Mitochondrion outer membrane Mitochondrion inner membrane. Mitochondrion matrix. Note: Predominantly associated with intracytoplasmic vesicular and membranous structures (By similarity). Localized in the cytoplasm and associated with cellular membrane structures Predominantly associated with the mitochondrial outer membrane of the mitochondria. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes. Tissue Location: Expressed in the brain. Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen Expression is particularly high in brain dopaminoceptive areas. The following patways have been known to be associated with this gene. Death, Disease Models, Animal, Inflammation, Movement Disorders, Nerve Degeneration, Nervous System Diseases, Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease, Secondary, Parkinsonian Disorders are some of the diseases may be linked to PARK8 (LRRK2) Antibody (L893) Blocking Peptide. LRRK2 also interacts with the following gene(s): ARFGAP1, CDC37, EIF4EBP1, HSPA8, MAP1B, MBP, MSN, SNCA. Blood, Brain, Embryonic Tissue, Eye, Intestine, Kidney, Liver, Lung, Nerve, Skin tissues are correlated with this protein.