|The LIN28A lin28a (Catalog #MBS9218222) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The LIN28A lin28a product has the following accession number(s) (GI #74752750) (NCBI Accession #Q9H9Z2.1) (Uniprot Accession #Q9H9Z2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Acts as a \'translational enhancer\', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5\'-GGAG-3\' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5\'-GGAG-3\' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
Cellular Location: Cytoplasm. Nucleus, nucleolus. Note: Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules. Tissue Location: Expressed in embryonic stem cells (ES cells), placenta and testis. Embryonic Tissue, Ovary, Placenta, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Disease Models, Animal, Hypertrophy, Inflammation, Kidney Diseases, Liver Neoplasms, Neoplasms, Experimental, Neurobehavioral Manifestations are some of the diseases may be linked to LIN28A Antibody (Center) Blocking peptide.