LIMK1 peptide product blog
Tags: LIMK1; Peptide; LIMK1 (C-terminus) Peptide; LIMK1 peptide;
The LIMK1 limk1 (Catalog #MBS474011) is a Peptide and is intended for research purposes only. The product is available for immediate purchase.ELISA: 50 ng/well
Western Blot: 1:1,000. Researchers should empirically determine the suitability of the LIMK1 limk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The LIMK1 limk1 product has the following accession number(s) (GI #4505001) (NCBI Accession #NP_002305.1) (Uniprot Accession #P53667). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Peptide Sequence: LIMK1 (C-terminu s) synthetic peptide correspond ing to amino acids at the C-terminus of human LIMK1. This sequence is conserved in rat and mouse LIMK1, and is not found in LIMK2.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their aminoterminal regulatory domains. LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, PAKs, and ROCK. PAK1 and ROCK phosphorylate LIMK1 or LIMK2 at the conserved Thr-508 or Thr-505 residues in the activation loop, increasing LIMK activity. In addition, VEGF-induced stress fiber formation has been linked to p38-mediated activation of LIMK through MK-2 phosphorylation of Ser-323. Activated LIM kinases inhibit the actin depolymerization activity of cofilin by phosphorylation at the amino-terminal Ser-3 residue of cofilin. In addition, LIMKs may have a function in the nucleus. It has been shown that the nuclear localization of LIMKs can mediate suppression of Rac/Cdc42-mediated cyclin D1 expression. This effect of LIMKs was independent of cofilin phosphorylation and the regulation of actin dynamics.
The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Eye, Heart, Kidney, Liver, Lung, Nerve tissues are correlated with this protein. LIMK1 also interacts with the following gene(s): BMPR2, CDKN1C, CFL1, LIMK2, PAK1, PAK2, PAK4, PXN, ROCK1, SSH1. Carcinoma, Central Nervous System Diseases, Congenital Abnormalities, Drug Toxicity, Inflammation, Leukemia, Lung Diseases, Neoplasm Metastasis, Neurodegenerative Diseases, Vascular Diseases are some of the diseases may be linked to LIMK1 (C-terminus) Peptide.