LIG3 blocking peptide product blog
Tags: Blocking Peptide; LIG3; LIG3 blocking peptide;
The LIG3 lig3 (Catalog #MBS9221425) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The LIG3 lig3 product has the following accession number(s) (GI #251757259) (NCBI Accession #P49916.2) (Uniprot Accession #P49916). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Cellular Location: Isoform 1: Mitochondrion Note: Contains an N-terminal mitochondrial transit peptide Isoform 3: Nucleus. Note: Lacks the N-terminal mitochondrial transit peptide. Tissue Location: Testis, thymus, prostate and heart. The following patways have been known to be associated with this gene. LIG3 also interacts with the following gene(s): PCNA, PNKP, POLB, TDP1, XRCC1, XRCC6. Anemia, Cardiovascular Diseases, Chromosome Aberrations, Fetal Death, Heart Diseases, Hyperglycemia, Infertility, Female, Lung Neoplasms, Ovarian Neoplasms, Vascular Diseases are some of the diseases may be linked to LIG3 Antibody (C-term) Blocking Peptide. Bladder, Blood, Brain, Embryonic Tissue, Lung, Muscle, Ovary, Pharynx, Skin, Uncharacterized Tissue tissues are correlated with this protein.