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Leukotactin/Mip-5 lysate product blog

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Posted on 2018-01-12 07:45:35 by mybiosource_staff
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Tags: Lysate; Leukotactin/Mip-5; Leukotactin/Mip-5 lysate;
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The Leukotactin/Mip-5 n/a (Catalog #MBS570449) is a Lysate and is intended for research purposes only. The product is available for immediate purchase. The Leukotactin/Mip-5 - Control Lysate reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Leukotactin/Mip-5 can be used in a range of immunoassay formats including, but not limited to, Activity Assay, Western Blot (WB).
Detects Keratin 5 & 8 by Western blot. Detects a 58 kDa band, corresponding to Keratin 5, and a 52.5 kDa band, corresponding to Keratin 8. Researchers should empirically determine the suitability of the Leukotactin/Mip-5 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Leukotactin-1 (Lkn-1), also known as Macrophage inflammatory protein 1 delta (MIP-1), MIP-5, HCC-2, and NCC-3, is a novel human CC chemokine whose gene was mapped to human chromosome 17 adjacent to the HCC-1 gene. Lkn-1, together with mouse C10, mouse MIP-1 and human MPIF-1, constitute a subgroup of CC chemokines which contain six instead of four conserved cysteine residues. The two additional cysteine residues in Lkn-1 have been shown to form a third disulfide bond. Lkn-1 cDNA encodes a 113 amino acid precursor protein with a putative signal peptide of 21 aa residues that is cleaved to generate a 92 amino acid mature protein. In recombinant Lkn-1 preparations produced in insect cells and in yeast, amino-terminal truncations were found to have occurred. The major forms of Lkn-1 secreted by insect cells and yeast were reported to be proteins of 68 and 66 amino acids, respectively. The full length and the amino-terminal truncated forms of human Lkn-1 have been shown to be potent chemoattractants for monocytes and T-lymphocytes. These proteins can also chemoattract eosinophils and have been shown to induce calcium flux in human CCR-1 transfected cells. Additionally, Lkn-1 can suppress colony formation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors.

Leukotactin/Mip-5 n/a

Source Note: Hybridoma produced by the fusion of splenocytes from mice immunized with cytoskeleton preparation of HeLa cells and mouse myeloma cells.
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