LDE225 kinase inhibitor product blog
Tags: Kinase Inhibitor; LDE225; LDE225 kinase inhibitor;
The LDE225 n/a (Catalog #MBS8506586) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the LDE225 (NVP-LDE225) with the following immunoassay(s):
Testing Data
LDE225 (NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 mumol/l. Topical application of a 1% LDE225 (NVP-LDE225) solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution. [1][2].
Solubility: DMSO >=97 mg/mL - Water <1 mg/mL - Ethanol >=97 mg/mL. Formula: C26H26F3N3O3
CAS Number: 956697-53-3.