Lats2 blocking peptide product blog
Tags: Blocking Peptide; Lats2; LATS2 blocking peptide;
The Lats2 lats2 (Catalog #MBS9224297) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The Lats2 lats2 product has the following accession number(s) (GI #52783135) (NCBI Accession #Q7TSJ6.1) (Uniprot Accession #Q7TSJ6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (By similarity).
Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Nucleus Note: Colocalizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis (By similarity). Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis. Translocates to the nucleus upon mitotic stress by nocodazole treatment (By similarity). Tissue Location: Expressed at high levels in ovary and testis and at lower levels in all other tissues examined. Lats2 also interacts with the following gene(s): Amot, Jub, Mob1a, Mob1b, Sav1, Stk3, Stk4, Wwc1, Wwtr1, Yap1. The following patways have been known to be associated with this gene. Blood, Embryonic Tissue, Eye, Heart, Kidney, Liver, Lung, Lymph Node, Prostate, Skin tissues are correlated with this protein. Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Disease Models, Animal, Genital Diseases, Male, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasms, Experimental, Nervous System Diseases, Ovarian Neoplasms are some of the diseases may be linked to Mouse Lats2 Antibody(C-term) Blocking peptide.