|The Lass1 cers1 (Catalog #MBS396429) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. The Lass1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Lass1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Lass1 cers1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Lass1 cers1 product has the following accession number(s) (GI #11641421) (NCBI Accession #NP_067090.1) (Uniprot Accession #P27544). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein.
The following patways have been known to be associated with this gene. Brain, Embryonic Tissue, Lung, Muscle, Nerve, Skin tissues are correlated with this protein. Lass1 also interacts with the following gene(s): CLN8, GDF1, SPTLC1, SPTLC3. Inflammation, Metabolic Diseases, Neoplasms are some of the diseases may be linked to Lass1.