L3MBTL1 blocking peptide product blog
Tags: Blocking Peptide; L3MBTL1; L3MBTL1 blocking peptide;
The L3MBTL1 l3mbtl1 (Catalog #MBS9230411) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The L3MBTL1 l3mbtl1 product has the following accession number(s) (GI #325511398) (NCBI Accession #Q9Y468.3) (Uniprot Accession #Q9Y468). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a \'reader\' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at \'Lys-26\' (H1bK26me1 and H1bK26me2) and histone H4 at \'Lys-20\' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at \'Lys-382\', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at \'Lys-860\'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Cellular Location: Nucleus. Note: Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex. Tissue Location: Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. The following patways have been known to be associated with this gene. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Nervous System Diseases are some of the diseases may be linked to L3MBTL1 Blocking Peptide (Center). Blood, Bone, Brain, Embryonic Tissue, Muscle, Placenta tissues are correlated with this protein.