KPNB1 blocking peptide product blog
Tags: KPNB1; Blocking Peptide; KPNB1 blocking peptide;
The KPNB1 kpnb1 (Catalog #MBS9226357) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The KPNB1 kpnb1 product has the following accession number(s) (GI #20981701) (NCBI Accession #Q14974.2) (Uniprot Accession #Q14974). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.
Cellular Location: Cytoplasm. Nucleus envelope. The following patways have been known to be associated with this gene. Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Hypertrophy, Inflammation, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Nervous System Diseases are some of the diseases may be linked to KPNB1 Antibody (N-term) Blocking Peptide. Blood, Bone, Brain, Eye, Heart, Kidney, Liver, Lung, Nerve, Spinal Cord tissues are correlated with this protein.