|The KNG1 kng1 (Catalog #MBS9218559) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The KNG1 kng1 product has the following accession number(s) (GI #124056474) (NCBI Accession #P01042.2) (Uniprot Accession #P01042). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.
Cellular Location: Secreted, extracellular space. Tissue Location: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. Atherosclerosis, Carcinoma, Hepatocellular, Cardiovascular Diseases, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Liver Diseases, Nervous System Diseases, Prenatal Exposure Delayed Effects are some of the diseases may be linked to KNG1 Antibody (N-term) Blocking peptide. The following patways have been known to be associated with this gene. Brain, Kidney, Liver, Prostate tissues are correlated with this protein.