|The KLK8 klk8 (Catalog #MBS9226062) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The KLK8 klk8 product has the following accession number(s) (GI #6093536) (NCBI Accession #O60259.1) (Uniprot Accession #O60259). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Cellular Location: Secreted. Cytoplasm. Note: Shows a cytoplasmic distribution in the keratinocytes. Tissue Location: Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus Isoform 1 and isoform 2 are found in fetal brain and placenta Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. Adenocarcinoma, Breast Neoplasms, Carcinoma, Hypertrophy, Inflammation, Lung Neoplasms, Memory Disorders, Neoplasms, Experimental, Seizures, Uterine Cervical Neoplasms are some of the diseases may be linked to Kallikrein 8 Antibody (Center) Blocking peptide. Brain, Esophagus, Liver, Lung, Lymph Node, Mammary Gland, Placenta, Skin, Stomach, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene.