KIT blocking peptide product blog
Tags: Blocking Peptide; KIT; KIT blocking peptide; KIT (T274);
The KIT kit (Catalog #MBS9225299) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The KIT kit product has the following accession number(s) (GI #125472) (NCBI Accession #P10721.1) (Uniprot Accession #P10721). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cytoplasm. Note: Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. Tissue Location: Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells. Breast Neoplasms, Gastrointestinal Stromal Tumors, Heart Diseases, Inflammation, Leukemia, Myeloid, Acute, Liver Diseases, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis are some of the diseases may be linked to Phospho-KIT(T274) Antibody Blocking peptide. The following patways have been known to be associated with this gene. Brain, Embryonic Tissue, Heart, Intestine, Kidney, Liver, Lung, Muscle, Nerve, Skin tissues are correlated with this protein. KIT also interacts with the following gene(s): DOK1, EPOR, GRB2, KITLG, PIK3CG, PIK3R1, PTPN11, SOCS6, STAT1, STAT5B.