KISS1 blocking peptide product blog
Tags: KISS1; Blocking Peptide; KISS1 blocking peptide;
The KISS1 kiss1 (Catalog #MBS9230077) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The KISS1 kiss1 product has the following accession number(s) (GI #292495092) (NCBI Accession #Q15726.4) (Uniprot Accession #Q15726). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
Cellular Location: Secreted. Tissue Location: Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Disorders of Sex Development, Genital Diseases, Female, Infertility, Female, Infertility, Male, Male Urogenital Diseases, Neoplasm Metastasis, Puberty, Delayed, Puberty, Precocious are some of the diseases may be linked to KISS1 Blocking Peptide (C-Term). Bone, Brain, Embryonic Tissue, Heart, Intestine, Lung, Placenta, Prostate, Skin, Testis tissues are correlated with this protein. KISS1 also interacts with the following gene(s): GNRH1, GNRH2, GNRHR, KISS1R, NPFFR1, PROKR2, TAC3, TACR3.