JNJ-26481585 kinase inhibitor product blog
Tags: Kinase Inhibitor; JNJ-26481585; JNJ-26481585 kinase inhibitor;
The JNJ-26481585 n/a (Catalog #MBS8506218) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the JNJ-26481585 with the following immunoassay(s):
Testing Data
JNJ-26481585 is an orally bioavailable, second-generation, hydroxamic acid-based HDAC inhibitor with an IC50 of 2.43 nM for 5T33MMvt cells. JNJ-26481585 has potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. [1] In vitro, JNJ-26481585 induced caspase cascade activation and upregulation of p21, resulting in apoptosis and cell cycle arrest in the myeloma cells at low nanomolar concentrations. When the 5T2MM-bearing mice were treated with JNJ-26481585, there were a reduction of the tumor load and a significant decrease in angiogenesis. [2].
Solubility: DMSO >=79mg/mL - Water >=50mg/mL - Ethanol <1mg/mL. Formula: C21H26N6O2
CAS Number: 875320-29-9.