Jarid2 blocking peptide product blogThe Jarid2 jarid2 (Catalog #MBS9230140) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Jarid2 jarid2 product has the following accession number(s) (GI #2498495) (NCBI Accession #Q62315.1) (Uniprot Accession #Q62315). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of \'Lys-27\' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of \'Lys-9\' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Cellular Location: Nucleus. Note: Colocalizes with the PRC2 complex on chromatin. Tissue Location: Widely expressed in embryos. In adults, expressed at high levels in heart, skeletal muscle, brain and thymus. Jarid2 also interacts with the following gene(s): Aebp2, Eed, Ezh2, Kdm3a, Nkx2-5, Notch1, Suz12. The following patways have been known to be associated with this gene. Autism Spectrum Disorder, Cardiovascular Diseases, Congenital Abnormalities, Heart Defects, Congenital, Heart Diseases, Heart Failure, Hypertrophy, Inflammation, Lung Neoplasms, Neural Tube Defects are some of the diseases may be linked to Mouse Jarid2 Blocking Peptide (C-term). Bone Marrow, Brain, Embryonic Tissue, Heart, Liver, Lung, Pancreas, Skin, Spleen, Thymus tissues are correlated with this protein.