Irak2 blocking peptide product blogThe Irak2 irak2 (Catalog #MBS9221474) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The Irak2 irak2 product has the following accession number(s) (GI #81866246) (NCBI Accession #Q8CFA1.2) (Uniprot Accession #Q8CFA1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Tissue Location: Ubiquitously expressed, with a higher expression observed in brain, spleen and liver. Isoform 1 and isoform 2 are considered agonist and isoform 3 and isoform 4 are considered antagonist. The following patways have been known to be associated with this gene. Irak2 also interacts with the following gene(s): Il1b, Il1r1, Il1rap, Irak1, Irak4, Myd88, Tab1, Tab2, Tollip, Traf6. Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Inflammation, Liver Diseases, Lung Diseases, Lung Injury, Necrosis, Nervous System Diseases, Pneumonia are some of the diseases may be linked to Mouse Irak2 Antibody (C-term) Blocking Peptide. Blood, Bone, Bone Marrow, Brain, Intestine, Kidney, Liver, Lung, Skin, Spleen tissues are correlated with this protein.