IRAK1 blocking peptide product blog
Tags: IRAK1; IRAK; Blocking Peptide; IRAK1 blocking peptide;
The IRAK1 irak1 (Catalog #MBS9227269) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The IRAK1 irak1 product has the following accession number(s) (GI #8928535) (NCBI Accession #P51617.2) (Uniprot Accession #P51617). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
Cellular Location: Cytoplasm. Nucleus. Lipid droplet. Note: Translocates to the nucleus when sumoylated RSAD2/viperin recruits it to the lipid droplet (By similarity). Tissue Location: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. The following patways have been known to be associated with this gene. Adenocarcinoma, Arthritis, Rheumatoid, Cardiovascular Diseases, Disease Models, Animal, Hepatitis, Inflammation, Kidney Diseases, Liver Diseases, Lung Injury, Necrosis are some of the diseases may be linked to IRAK Antibody (C-term) Blocking peptide. Blood, Bone, Brain, Intestine, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. IRAK1 also interacts with the following gene(s): IKBKG, IL1RAP, IRF5, IRF7, MECP2, MYD88, NFKBIA, TLR4, TOLLIP, TRAF6.