IP3 positive control product blog
Tags: IP3; Positive Control; IP3 receptor; IP3 positive control;
The IP3 itpr1 (Catalog #MBS542883) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IP3 receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Western Blot: 1:500. Researchers should empirically determine the suitability of the IP3 itpr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IP3 itpr1 product has the following accession number(s) (GI #269954690) (NCBI Accession #NP_001093422.2) (Uniprot Accession #Q14643). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Western Blot Positive Control Inositol 1, 4, 5-trisphosphate receptor type� isoform 1 Antibody
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Immunogen: Purified Protein
Expression: Widely expressed. Molecular Function: Calcium channel, Ion channel, Ligand-gated ion channel, Receptor
Structure: Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe
Subcellular Location: Endoplasmic Reticulum membrane; Multi-pass membrane protein. The following patways have been known to be associated with this gene. Atrophy, Brain Diseases, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Nervous System Diseases are some of the diseases may be linked to IP3 receptor Antibody Western Blot Positive Control. Blood, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein. IP3 also interacts with the following gene(s): BCL2, CALM1, EPB41L1, MRVI1, ORAI1, STIM1, TRPC1, TRPC3.