Indirubin kinase inhibitor product blog
Tags: Kinase Inhibitor; Indirubin; Indirubin kinase inhibitor;
The Indirubin n/a (Catalog #MBS8506275) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given inhibitor. We\'ve tested the Indirubin with the following immunoassay(s):
Testing Data
Indirubin is a potent cyclin-dependent kinases and GSK-3beta inhibitor with IC50 of about 75 nM and 0.19 muM. It inhibits CDK5-and GSK-3beta-mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation. It suppressed tumor necrosis factor (TNF)-induced NF-kappaB activation in a dose-and time-dependent manner. Indirubin also suppressed the NF-kappaB activation induced by various inflammatory agents and carcinogens. Further studies showed that indirubin blocked the phosphorylation and degradation of IkappaBalpha through the inhibition of activation of IkappaBalpha kinase and phosphorylation and nuclear translocation of p65. NF-kappaB reporter activity induced by TNFR1, TNF receptor-associated death domain, TRAF2, TAK1, NF-kappaB-inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection. [1][2].
Solubility: DMSO >=53 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL. Formula: C16H10N2O2
CAS Number: 479-41-4.