Ilomastat, Liquid inhibitor product blog
Tags: Inhibitor; Ilomastat, Liquid; Ilomastat, Liquid inhibitor;
The Ilomastat, Liquid n/a (Catalog #MBS655478) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase.Suitable for use in Cell Culture.
Dilution:
For use in cultured cells: 10-2SuM. GM6001 will precipitate from solutions exceeding 100uM. Use low salt buffers. Researchers should empirically determine the suitability of the Ilomastat, Liquid n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
GM6001 MMP InhIbItor, also known as 1I0mastat or N-[(2R)-2-(hydroxamidocarbonylmethyl)- 4-methylpenta noyl]-L -tryptopha n methylamide, is a potent inhibitor of collagenase.
Reported Ki values are as follows (see Cialardy Ref):: Human MMP-1 (Fibroblast collagenase):
O.4nM
Human MMP-3 ~StromeIYSin): 27nM
Human MMP-2 72kD gelatinase): O.5nM
Human MMP-8 Neutrophil collagenase):
O.lnM
Human MMP-9 (92kD gelatinase): 0.2nM. Quality Control: H-NMR Spectrum: Conforms
Mass Spectrum: 389 [M+1]
Thin Layer Chromatography (ethylacetate:methanol = 6:1): Single spot
Buffer: SOmM Tris, pH 7.5, lS0mM NaCl, and 20mM CaCI2-2H20. It is recommended that the concentration of GM600 1 be determined upon dilution and confirmed prior to use. Relative concentrations in aqueous solutions may be determined by measuring absorbance of the solution(tyrosine) at 280nm.