ILK blocking peptide product blog
Tags: ILK; Blocking Peptide; ILK blocking peptide; ILK2/ILK1;
The ILK ilk (Catalog #MBS9226561) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The ILK ilk product has the following accession number(s) (GI #9973397) (NCBI Accession #Q13418.2) (Uniprot Accession #Q13418). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Cellular Location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Tissue Location: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Lung Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to ILK2/ILK1 Antibody (C-term) Blocking Peptide. The following patways have been known to be associated with this gene. ILK also interacts with the following gene(s): AKT1, GSK3B, ILKAP, ITGB1, LIMS1, LIMS2, PARVA, PARVB, PARVG, PXN. Blood, Bone, Brain, Embryonic Tissue, Heart, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein.