IL6 recombinant protein product blog
Tags: IL6; Recombinant Protein; IL6 recombinant protein;
The IL6 il6 (Catalog #MBS538066) is an Active Protein produced from Human and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL6 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL6 il6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The IL6 il6 product has the following accession number(s) (GI #10834984) (NCBI Accession #NP_000591.1) (Uniprot Accession #P05231). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of IL6 protein correspond ing to amino acids PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL6 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL6 signals through the IL6 receptor system that consists of two chains, IL6R an and gp130. Mouse IL6 is inactive on human cells, while both human and Mouse are equally active on Mouse cells.
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent Mouse 7TD1 cells is approximately 0.1 ng/ml, corresponding to a specific activity of approximately 1 x 10^7units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. The following patways have been known to be associated with this gene. IL6 also interacts with the following gene(s): CEBPB, FOS, IL6R, IL6ST, JUN, NFKB1, OSM, SOCS3, STAT1, STAT3. Blood, Bone, Brain, Connective Tissue, Eye, Kidney, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Arthritis, Rheumatoid, Atherosclerosis, Autoimmune Diseases, Breast Neoplasms, Diabetes Mellitus, Type 2, Inflammation, Ischemia, Myocardial Ischemia, Necrosis, Skin Diseases are some of the diseases may be linked to IL6 protein.