IL4R blocking peptide product blog
Tags: Blocking Peptide; IL4R; IL4R blocking peptide;
The IL4R il4r (Catalog #MBS9229207) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.The IL4R il4r product has the following accession number(s) (GI #124335) (NCBI Accession #P24394.1) (Uniprot Accession #P24394). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Isoform 1 and isoform 2 are highly expressed in activated T-cells. Blood, Bone, Bone Marrow, Brain, Heart, Kidney, Liver, Lung, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. IL4R also interacts with the following gene(s): IL13RA1, IL2RG, IL4, IL6, JAK1, JAK3, SOCS5, STAT6. Breast Neoplasms, Cardiovascular Diseases, Fibrosis, HIV Infections, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to IL4R Blocking Peptide (C-term).