IL33 recombinant protein product blog
Tags: Recombinant Protein; IL33; IL33 recombinant protein;
The IL33 il33 (Catalog #MBS539515) is an Active Protein produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL33 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL33 il33 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The IL33 il33 product has the following accession number(s) (GI #15559209) (NCBI Accession #NP_254274.1) (Uniprot Accession #O95760). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of IL33 protein correspond ing to amino acids SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL33 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL33 is a proinflammatory protein that shares structural and functional characteristics with the IL1 cytokine family. It binds and signals through the IL1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL33 induces production of TH2 cell related cytokines, including IL4, IL5 and IL13, and exerts multiple inflammation related bioactivities.
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse D10S cells is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. Asthma, Cardiovascular Diseases, Dermatitis, Atopic, Disease Models, Animal, Fibrosis, Heart Diseases, Hypersensitivity, Immediate, Inflammation, Lung Diseases, Necrosis are some of the diseases may be linked to IL33 protein (Mouse). IL33 also interacts with the following gene(s): CASP1, IL1RL1, IL6, ITGAM, KIT, TFF2, TNFSF11, VEGFA. Brain, Connective Tissue, Eye, Heart, Intestine, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.