IL22 recombinant protein product blog
Tags: Interleukin 22; Recombinant Protein; IL22 recombinant protein; IL22;
The IL22 il22 (Catalog #MBS400082) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase.The IL22 il22 product has the following accession number(s) (GI #10092625) (NCBI Accession #NP_065386.1) (Uniprot Accession #Q9GZX6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
The sequence of the N-terminal amino acids could not be determined indicating that the PEG moiety is attached to the N-terminus.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including interleukin 22 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Solubility: It is recommended to reconstitute the lyophilized pegylated mouse IL22 in sterile water or sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100ug/ml, which can then be further diluted with other aqueous solutions.
Protein Content: Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.26 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the DNAman computer analysis program of protein sequences.
Dimers and Aggregates: The purified mouse pegylated IL22 consists of > 90% monomers as determined by gel-filtration chromatography. Endotoxin: Less than 0.05 ng/ug (0.5 EU/ug) of recombinant pegylated IL-22.
Formulation: The protein was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3.
Biological Activity: murine IL-22 is biologically active when compared to standard using STAT3 phosphorylation assay in HepG cells. Its acrtivity in vitro is ~ 10% compared to the non-pegylated mIL22. The following patways have been known to be associated with this gene. IL22 also interacts with the following gene(s): IL10RA, IL10RB, IL17A, IL22RA1, IL22RA2, STAT1, STAT3, STAT5A. Colitis, Death, Dermatitis, Fibrosis, Hypersensitivity, Inflammation, Liver Diseases, Lung Diseases, Necrosis, Weight Loss are some of the diseases may be linked to Mouse interleukin 22 - pegylated. Blood tissues are correlated with this protein.