|The IL21 il21 (Catalog #MBS539572) is a Recombinant Protein produced from E.coli and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL21 can be used in a range of immunoassay formats including, but not limited to, User optimized.
Protein quantitation was carried out by two independent methods. 1. UV spectroscopy at 280 nm using the absorbency value of 0.54 as the extinction coefficient for a 0.1% (1mg/ml) solution. 2. Analysis by RP-HPLC, using a standard solution of IL-21 as a Reference Standard. Researchers should empirically determine the suitability of the IL21 il21 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL21 il21 product has the following accession number(s) (GI #11141875) (NCBI Accession #NP_068575.1) (Uniprot Accession #Q9HBE4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL21 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in na?ve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (
Bioactivity: ED50 = 1.0-10 ng/ml, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells. Biohazard: Use appropriate laboratory precautions when handling this product. Uncharacterized Tissue tissues are correlated with this protein. Autoimmune Diseases, Celiac Disease, Demyelinating Diseases, Hypersensitivity, Inflammation, Kidney Diseases, Liver Diseases, Lupus Erythematosus, Systemic, Necrosis, Neoplasms, Experimental are some of the diseases may be linked to IL21 protein. IL21 also interacts with the following gene(s): BCL6, FOXP3, GZMB, IL21R, IL2RG, IL5, PRDM1, STAT3, TBX21. The following patways have been known to be associated with this gene.