|The IL1RN il1rn (Catalog #MBS9226103) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The IL1RN il1rn product has the following accession number(s) (GI #124312) (NCBI Accession #P18510.1) (Uniprot Accession #P18510). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Cellular Location: Isoform 1: Secreted. Isoform 3: Cytoplasm. Tissue Location: The intracellular form of IL1RN is predominantly expressed in epithelial cells. Arthritis, Rheumatoid, Disease Models, Animal, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Liver Diseases, Necrosis, Pain, Skin Diseases are some of the diseases may be linked to IL1RN Antibody (Center) Blocking Peptide. The following patways have been known to be associated with this gene. IL1RN also interacts with the following gene(s): IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IRAK2, IRAK3, MYD88. Blood, Brain, Eye, Heart, Intestine, Liver, Lung, Skin, Spleen, Stomach tissues are correlated with this protein.