|The IL10 il10 (Catalog #MBS538121) is a Recombinant Protein produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s IL10 can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the IL10 il10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The IL10 il10 product has the following accession number(s) (GI #10835141) (NCBI Accession #NP_000563.1) (Uniprot Accession #P22301). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
Region of IL10 protein correspond ing to amino acids MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S.
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Our knowledge of the role of proteins in cellular processes is continually evolving. Most proteins, including IL10 are typically involved in one or more signaling pathways or biological processes. Professionally manufactured recombinant proteins are increasingly becoming essential and commonplace tools for elucidating new knowledge about the role of proteins in both health and disease.
Protein Type: Recombinant
Biological Significance: IL10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL10 inhibits the expression of proinflammatory cytokines such as IL1 and TNFa. Like IL4, IL10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL10 active on Mouse cells, but Mouse IL10 is inactive on human cells.
Bioactivity: Mouse IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of Mouse MC/9 cells. The ED50 was found to be 5 x 10^5 units/mg.
Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System: E Coli. Blood, Connective Tissue, Lung, Spleen, Uncharacterized Tissue tissues are correlated with this protein. IL10 also interacts with the following gene(s): FOXP3, GATA3, IL10RA, IL10RB, IL2, IL4, IL6, IL8, JUN, STAT6. Arthritis, Rheumatoid, Colitis, Genetic Predisposition to Disease, HIV Infections, Hypersensitivity, Immediate, Inflammation, Inflammatory Bowel Diseases, Kidney Diseases, Necrosis, Sepsis are some of the diseases may be linked to IL10 protein (Mouse). The following patways have been known to be associated with this gene.