IKZF1 blocking peptide product blogThe IKZF1 ikzf1 (Catalog #MBS9217490) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The IKZF1 ikzf1 product has the following accession number(s) (GI #5174501) (NCBI Accession #NP_006051.1) (Uniprot Accession #Q13422). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-An element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).
Cellular Location: Nucleus. Note: In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events (By similarity). Isoform Ik6: Cytoplasm. Tissue Location: Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. Abnormalities, Multiple, Cell Transformation, Neoplastic, Chromosome Aberrations, Inflammation, Lupus Erythematosus, Systemic, Lymphoma, Necrosis, Neoplasms, Experimental, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma are some of the diseases may be linked to IKZF1 Antibody (C-term) Blocking peptide. Blood, Bone, Bone Marrow, Liver, Lung, Lymph, Lymph Node, Prostate, Spleen, Thymus tissues are correlated with this protein. IKZF1 also interacts with the following gene(s): CHD4, CTBP1, GATA1, GATA3, HDAC1, SIN3A, SMARCA4. The following patways have been known to be associated with this gene.