|The IKBKE ikbke (Catalog #MBS9227571) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase.
The IKBKE ikbke product has the following accession number(s) (GI #14548079) (NCBI Accession #Q14164.1) (Uniprot Accession #Q14164). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG- I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at \'Ser-708\'. Phosphorylation of STAT1 at \'Ser-708\' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
Cellular Location: Cytoplasm. Nucleus. Nucleus, PML body. Note: Targeting to PML nuclear bodies upon DNA damage is TOPORS- dependent. Tissue Location: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon. The following patways have been known to be associated with this gene. IKBKE also interacts with the following gene(s): FOXO3, IFNB1, IRF3, NFKBIA, RELA, STAT3, TANK, TICAM1, TNF. Blood, Bone, Embryonic Tissue, Heart, Intestine, Kidney, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Atherosclerosis, Breast Neoplasms, Cardiovascular Diseases, Cell Transformation, Neoplastic, Disease Models, Animal, Inflammation, Liver Diseases, Necrosis, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to IKK epsilon (IKKE) Antibody (C-term) Blocking peptide.